<i>Schistosoma mansoni</i> infection is associated with decreased risk of respiratory allergy symptoms and low production of CCL2

Objectives We measured the production of cytokines, chemokines and antibodies involved in allergic responses sCD23 levels during Schistosoma mansoni infection. Methods Individuals (n = 164) were selected using ISAAC questionnaire parasitological exams. The subjects divided as follows: those infected individuals with allergy-related symptoms (A-I), only (A-NI); (NA-I); non-infected without (NA-NI). used supernatants from cell culture (mitogenic stimulation) to measure cytokine chemokine cytometric bead arrays. Serum anti-Ascaris lumbricoides (Asc) anti-Blomia tropicalis IgE ImmunoCAP, was ELISA. Results infection associated a lower risk symptoms. In A-I, there higher TNF-α, IL-10, IL-6, IFN-γ CXCL8 than NA-NI group, TNF-α IL-6 also at compared A-NI group. Levels CXCL8, total anti-Asc IgE, well numbers eosinophils, NA-I NA-NI, AI NA-I, less CCL2 NA-NI. There no differences IL-2, IL-4, IL-17, CCL5, IgE. Conclusions Patients (simultaneously) had IL-10; due infection, increased CCL2. These data may characterize deviation Th1 or attenuation Th2 response allergy sufferers areas endemic for schistosomiasis.